Exploring personalized structural connectomics for moderate to severe traumatic brain injury.

ABSTRACT: Graph theoretical analysis of the structural connectome has been employed successfully to characterize brain network alterations in patients with traumatic brain injury (TBI). However, heterogeneity in neuropathology is a well-known issue in the TBI population, such that group comparisons of patients against controls are confounded by within-group variability. Recently, novel single-subject profiling approaches have been developed to capture inter-patient heterogeneity. We present a personalized connectomics approach that examines structural brain alterations in five chronic patients with moderate to severe TBI who underwent anatomical and diffusion magnetic resonance imaging. We generated individualized profiles of lesion characteristics and network measures (including personalized graph

SUBMITTER: Imms P 

PROVIDER: S-EPMC10270710 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature