Nonoptimal component placement of the human connectome supports variable brain dynamics.

ABSTRACT: Neural systems are shaped by multiple constraints, balancing region communication with the cost of establishing and maintaining physical connections. It has been suggested that the lengths of neural projections be minimized, reducing their spatial and metabolic impact on the organism. However, long-range connections are prevalent in the connectomes across various species, and thus, rather than rewiring connections to reduce length, an alternative theory proposes that the brain minimizes total wiring length through a suitable positioning of regions, termed component placement optimization. Previous studies in nonhuman primates have refuted this idea by identifying a nonoptimal component placement, where a spatial rearrangement of brain regions in silico leads to a reduced total wirin

SUBMITTER: Hayward CJ 

PROVIDER: S-EPMC10270717 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature