Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose-response meta-analysis of prospective studies.

ABSTRACT:

Objective

To assess the association between maternal caffeine intake and risk of pregnancy loss using a systematic review and meta-analysis.

Design

Categorical and dose-response meta-analysis of prospective studies.

Setting

Relevant articles were identified by searching MEDLINE and SCOPUS databases through 30 January 2015. Two authors independently extracted information from eligible studies. Random-effects models were used to derive the summary relative risks (RR) and corresponding 95% CI for specific categories of caffeine consumption and for a continuous association using generalized least-squares trend estimation.

Subjects

A total of 130 456 participants and 3429 cases in fourteen included studies.

Results

Compared with the reference category with no

SUBMITTER: Chen LW 

PROVIDER: S-EPMC10271029 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature