Associations between cruciferous vegetable intake and selected biomarkers among women scheduled for breast biopsies.

ABSTRACT:

Objective

To examine the relationship between dietary cruciferous vegetable intake and selected tumour biomarkers for histone acetylation (H3K9ac, H3K18ac, HDAC3 and HDAC6), proliferation (Ki-67) and cell-cycle regulation (p21) from breast tissue.

Design

The study used baseline data of women recruited to participate in a clinical trial of sulforaphane supplement. Dietary cruciferous vegetable intake was collected through a validated Arizona Cruciferous Vegetable Intake Questionnaire. Breast tissue was obtained from biopsy samples. Spearman correlations were calculated between intake of specific cruciferous vegetables and biomarkers. Tissue biomarkers were log2-transformed to obtain approximate normality. Linear regression analyses were conducted to examine associations betwe

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10271091 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature