Serum Mac-2 Binding Protein Glycosylation Isomer Concentrations Are Associated With Incidence of Type 2 Diabetes.

ABSTRACT:

Context

Serum Mac-2 binding protein glycosylation isomer (M2BPGi) concentrations are known to be an indicator of chronic liver injury and fibrosis.

Objective

This study aimed to investigate the association between serum M2BPGi concentrations and the development of type 2 diabetes in a Japanese community.

Methods

A total of 2143 community-dwelling Japanese individuals aged 40-79 years without diabetes at baseline were followed up for 7 years. Serum M2BPGi concentrations were divided into quintiles: Q1, ≤0.37 cutoff index (COI); Q2, 0.38-0.49 COI; Q3, 0.50-0.62 COI; Q4, 0.62-0.80 COI; and Q5, ≥0.81 COI. Cox proportional hazards models were used to estimate hazard ratios and 95% CIs for the development of type 2 diabetes.

Results

During the follow-up period, 219 i

SUBMITTER: Higashioka M 

PROVIDER: S-EPMC10271221 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature