High miR-126-3p levels associated with cardiovascular events in a general population.

ABSTRACT:

Background

Endothelial dysfunction is a forerunner of atherosclerosis, leading to cardiovascular disease, and albuminuria is a marker of endothelial dysfunction. Circulating levels of microRNAs are emerging as potential biomarkers for cardiovascular disease. Here we estimate the predictive value of a plasma microRNAs signature associated with albuminuria in the incidence of cardiovascular events.

Methods

Plasma microRNAs quantified in hypertensive patients by next generation sequencing were validated in a cohort of patients and controls by real-time quantitative PCR. The microRNAs found to be associated with albuminuria were analysed for their prognostic value in predicting cardiovascular events incidence on a retrospective, population-based study (Hortega Study), using Cox

SUBMITTER: Martinez-Arroyo O 

PROVIDER: S-EPMC10271715 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature