Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans.

ABSTRACT:

Background

This study used admixture mapping to prioritize the genetic regions associated with Alzheimer's disease (AD) in African American (AA) individuals, followed by ancestry-aware regression analysis to fine-map the prioritized regions.

Methods

We analyzed 10,271 individuals from 17 different AA datasets. We performed admixture mapping and meta-analyzed the results. We then used regression analysis, adjusting for local ancestry main effects and interactions with genotype, to refine the regions identified from admixture mapping. Finally, we leveraged in silico annotation and differential gene expression data to prioritize AD-related variants and genes.

Results

Admixture mapping identified two genome-wide significant loci on chromosomes 17p13.2 (p = 2.2 × 10^-5

SUBMITTER: Rajabli F 

PROVIDER: S-EPMC10272044 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature