Gene-environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures.

ABSTRACT:

Background

We previously reported an association between household chemical exposures and an increased risk of paediatric-onset multiple sclerosis.

Methods

Using a case-control paediatric multiple sclerosis study, gene-environment interaction between exposure to household chemicals and genotypes for risk of paediatric-onset multiple sclerosis was estimated.Genetic risk factors of interest included the two major HLA multiple sclerosis risk factors, the presence of DRB1*15 and the absence of A*02, and multiple sclerosis risk variants within the metabolic pathways of common household toxic chemicals, including IL-6 (rs2069852), BCL-2 (rs2187163) and NFKB1 (rs7665090).

Results

490 paediatric-onset multiple sclerosis cases and 716 control

SUBMITTER: Nasr Z 

PROVIDER: S-EPMC10272045 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature