Predicting the effect of different folate doses on [⁶⁸Ga]Ga-PSMA-11 organ and tumor uptake using physiologically based pharmacokinetic modeling.

ABSTRACT:

Background

Folate intake might reduce [⁶⁸Ga]Ga-PSMA-11 uptake in tissues due to a competitive binding to the PSMA receptor. For diagnostic imaging, this could impact decision making, while during radioligand therapy this could affect treatment efficacy. The relationship between folate dose, timing of dosing and tumor and organ uptake is not well established. The aim of this study was to develop a physiologically based pharmacokinetic (PBPK) model to predict the effect of folates on [⁶⁸Ga]Ga-PSMA-11 PET/CT uptake in salivary glands, kidneys and tumors.

Methods

A PBPK model was developed for [⁶⁸Ga]Ga-PSMA-11 and folates (folic acid and its metabolite 5-MTHF), with compartments added that represent salivary glands and tumor. Reactions describing

SUBMITTER: Siebinga H 

PROVIDER: S-EPMC10272068 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature