A dorsomedial prefrontal cortex-based dynamic functional connectivity model of rumination.

ABSTRACT: Rumination is a cognitive style characterized by repetitive thoughts about one's negative internal states and is a common symptom of depression. Previous studies have linked trait rumination to alterations in the default mode network, but predictive brain markers of rumination are lacking. Here, we adopt a predictive modeling approach to develop a neuroimaging marker of rumination based on the variance of dynamic resting-state functional connectivity and test it across 5 diverse subclinical and clinical samples (total n = 288). A whole-brain marker based on dynamic connectivity with the dorsomedial prefrontal cortex (dmPFC) emerges as generalizable across the subclinical datasets. A refined marker consisting of the most important features from a virtual lesion analysis further predicts dep

SUBMITTER: Kim J 

PROVIDER: S-EPMC10272121 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature