Remodeling of the focal adhesion complex by hydrogen-peroxide-induced senescence.

ABSTRACT: Cellular senescence is a phenotype characterized by cessation of cell division, which can be caused by exhaustive replication or environmental stress. It is involved in age-related pathophysiological conditions and affects both the cellular cytoskeleton and the prime cellular mechanosensors, focal adhesion complexes. While the size of focal adhesions increases during senescence, it is unknown if and how this is accompanied by a remodeling of the internal focal adhesion structure. Our study uses metal-induced energy transfer to study the axial dimension of focal adhesion proteins from oxidative-stress-induced senescent cells with nanometer precision, and compares these to unstressed cells. We influenced cytoskeletal tension and the functioning of mechanosensitive ion channels using drugs an

SUBMITTER: Grandy C 

PROVIDER: S-EPMC10272183 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature