Post-ischemic reorganization of sensory responses in cerebral cortex.

ABSTRACT:

Introduction

Sensorimotor integration is critical for generating skilled, volitional movements. While stroke tends to impact motor function, there are also often associated sensory deficits that contribute to overall behavioral deficits. Because many of the cortico-cortical projections participating in the generation of volitional movement either target or pass-through primary motor cortex (in rats, caudal forelimb area; CFA), any damage to CFA can lead to a subsequent disruption in information flow. As a result, the loss of sensory feedback is thought to contribute to motor dysfunction even when sensory areas are spared from injury. Previous research has suggested that the restoration of sensorimotor integration through reorganization or de novo neuronal connections is impo

SUBMITTER: Hayley P 

PROVIDER: S-EPMC10272353 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature