Dengue virus neutralizing antibody: a review of targets, cross-reactivity, and antibody-dependent enhancement.

ABSTRACT: Dengue is the most common viral infection spread by mosquitoes, prevalent in tropical countries. The acute dengue virus (DENV) infection is a benign and primarily febrile illness. However, secondary infection with alternative serotypes can worsen the condition, leading to severe and potentially fatal dengue. The antibody raised by the vaccine or the primary infections are frequently cross-reactive; however, weakly neutralizing, and during subsequent infection, they may increase the odds of antibody-dependent enhancement (ADE). Despite that, many neutralizing antibodies have been identified against the DENV, which are thought to be useful in reducing dengue severity. Indeed, an antibody must be free from ADE for therapeutic application, as it is pretty common in dengue infection and escalat

SUBMITTER: Sarker A 

PROVIDER: S-EPMC10272415 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature