Exploration of the impact of multimode thermal therapy versus radiofrequency ablation on CD8⁺ T effector cells of liver malignancies based on single cell transcriptomics.

ABSTRACT:

Introduction

Multimode thermal therapy (MTT) is an innovative interventional therapy developed for the treatment of liver malignancies. When compared to the conventional radiofrequency ablation (RFA), MTT typically offers improved prognosis for patients. However, the effect of MTT on the peripheral immune environment and the mechanisms underlying the enhanced prognosis have yet to be explored. The aim of this study was to further investigate the mechanisms responsible for the difference in prognosis between the two therapies.

Methods

In this study, peripheral blood samples were collected from four patients treated with MTT and two patients treated with RFA for liver malignancies at different time points before and after the treatment. Single cell sequencing was performed on

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10272448 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature