Exploring the genetic association of allergic diseases with cardiovascular diseases: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

In observational and experimental studies, allergic diseases (AD) have been reported to be associated with some types of cardiovascular diseases (CVD), as both share common pathophysiological processes involving inflammation and metabolic disorders. However, the direction of the causal association between them remains unclear. This Mendelian randomization (MR) study aims to examine the bidirectional causality between AD and CVD.

Methods

We utilized publicly available genome-wide association study (GWAS) summary statistics data from European participants in the UK Biobank and the IEU Open GWAS database. Genetic variants associated with AD, asthma, and CVD were identified and used as instrumental variables to investigate the genetically causal association between th

SUBMITTER: Wang S 

PROVIDER: S-EPMC10272545 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature