Intestinal fatty acid binding protein is associated with cardiac function and gut dysbiosis in chronic heart failure.

ABSTRACT:

Background

The gut microbiota in patients with chronic heart failure (HF) is characterized by low bacterial diversity and reduced ability to synthesize beneficial metabolites. These changes may facilitate leakage of whole bacteria or bacterial products from the gut into the bloodstream, which may activate the innate immune system and contribute to the low-grade inflammation seen in HF. In this exploratory cross-sectional study, we aimed to investigate relationships between gut microbiota diversity, markers of gut barrier dysfunction, inflammatory markers, and cardiac function in chronic HF patients.

Methods

In total, 151 adult patients with stable HF and left ventricular ejection fraction (LVEF) < 40% were enrolled. We measured lipopolysaccharide (LPS), LPS-binding protein (

SUBMITTER: Nendl A 

PROVIDER: S-EPMC10272617 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature