AIRRSHIP: simulating human B cell receptor repertoire sequences.

ABSTRACT:

Summary

Adaptive Immune Receptor Repertoire Sequencing is a rapidly developing field that has advanced understanding of the role of the adaptive immune system in health and disease. Numerous tools have been developed to analyse the complex data produced by this technique but work to compare their accuracy and reliability has been limited. Thorough, systematic assessment of their performance is dependent on the ability to produce high quality simulated datasets with known ground truth. We have developed AIRRSHIP, a flexible and fast Python package that produces synthetic human B cell receptor sequences. AIRRSHIP uses a comprehensive set of reference data to replicate key mechanisms in the immunoglobulin recombination process, with a particular focus on junctional complexity. Reperto

SUBMITTER: Sutherland C 

PROVIDER: S-EPMC10272706 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature