Aberrant expression of bone morphogenetic proteins in the disease progression and metastasis of breast cancer.

ABSTRACT:

Background

Bone morphogenetic proteins (BMPs) play crucial roles in the tumorigenesis and metastasis of cancers. Controversy remains about the exact implications of BMPs and their antagonists in breast cancer (BC), due to their diverse and complex biological functions and signalling. A comprehensive study of the whole family and their signalling in breast cancer is provoked.

Methods

Aberrant expression of BMP, BMP receptors and antagonists in primary tumours in breast cancer were analysed by using TCGA-BRCA and E-MTAB-6703 cohorts. Related biomarkers including ER, HER, proliferation, invasion, angiogenesis, lymphangiogenesis and bone metastasis were involved to identify the relationship with BMPs in breast cancer.

Results

The present study showed BMP8B was significant

SUBMITTER: Liu M 

PROVIDER: S-EPMC10272747 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature