NOD mouse dorsal root ganglia display morphological and gene expression defects before and during autoimmune diabetes development.

ABSTRACT:

Introduction

During the development of Autoimmune Diabetes (AD) an autoimmune attack against the Peripheral Nervous System occurs. To gain insight into this topic, analyses of Dorsal Root Ganglia (DRG) from Non-Obese Diabetic (NOD) mice were carried out.

Methods

Histopathological analysis by electron and optical microscopy in DRG samples, and mRNA expression analyzes by the microarray technique in DRG and blood leukocyte samples from NOD and C57BL/6 mice were performed.

Results

The results showed the formation of cytoplasmic vacuoles in DRG cells early in life that could be related to a neurodegenerative process. In view of these results, mRNA expression analyses were conducted to determine the cause and/or the molecules involved in this suspected disorder. The result

SUBMITTER: Corral-Pujol M 

PROVIDER: S-EPMC10272810 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature