Neuropsychological profile of CSF1R-related leukoencephalopathy.

ABSTRACT:

Introduction

The neuropsychological profile of CSF1R-related leukoencephalopathy (CRL) is undefined. This study defines the profile, contrasts it with that of other dementia syndromes, and highlights measures sensitive to cognitive impairment.

Methods

We administered a standardized battery of neuropsychological tests to five consecutive CRL cases.

Results

The neuropsychological profile of CRL reflects impaired general cognitive function, processing speed, executive function, speeded visual problem solving, verbal fluency, and self-reported depression and anxiety. Confrontation naming and memory are preserved. Within cognitive domains, certain measures more frequently identified impairment than others.

Discussion

CRL impairs general cognitive function, processin

SUBMITTER: Rush BK 

PROVIDER: S-EPMC10272847 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature