Genomic variation during culture adaptation of genetically complex Plasmodium falciparum clinical isolates.

ABSTRACT: Experimental studies on the biology of malaria parasites have mostly been based on laboratory-adapted lines, but there is limited understanding of how these may differ from parasites in natural infections. Loss-of-function mutants have previously been shown to emerge during culture of some Plasmodium falciparum clinical isolates in analyses focusing on single-genotype infections. The present study included a broader array of isolates, mostly representing multiple-genotype infections, which are more typical in areas where malaria is highly endemic. Genome sequence data from multiple time points over several months of culture adaptation of 28 West African isolates were analysed, including previously available sequences along with new genome sequences from additional isolates and time

SUBMITTER: Claessens A 

PROVIDER: S-EPMC10272863 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature