The highly diverse plasmid population found in <i>Escherichia coli</i> colonizing travellers to Laos and its role in antimicrobial resistance gene carriage.

ABSTRACT: Increased colonization by antimicrobial-resistant organisms is closely associated with international travel. This study investigated the diversity of mobile genetic elements involved with antimicrobial resistance (AMR) gene carriage in extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli that colonized travellers to Laos. Long-read sequencing was used to reconstruct complete plasmid sequences from 48 isolates obtained from the daily stool samples of 23 travellers over a 3 week period. This method revealed a collection of 105 distinct plasmids, 38.1 % (n=40) of which carried AMR genes. The plasmids in this population were diverse, mostly unreported and included 38 replicon types, with F-type plasmids (n=23) the most prevalent amongst those carrying AMR gen

SUBMITTER: Snaith AE 

PROVIDER: S-EPMC10272864 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature