Humanization for neurological disease modeling: A roadmap to increase the potential of Drosophila model systems.

ABSTRACT: Neuroscience and neurology research is dominated by experimentation with rodents. Around 75% of neurology disease-associated genes have orthologs in Drosophila melanogaster, the fruit fly amenable to complex neurological and behavioral investigations. However, non-vertebrate models including Drosophila have so far been unable to significantly replace mice and rats in this field of studies. One reason for this situation is the predominance of gene overexpression (and gene loss-of-function) methodologies used when establishing a Drosophila model of a given neurological disease, a strategy that does not recapitulate accurately enough the genetic disease conditions. I argue here the need for a systematic humanization approach, whereby the Drosophila orthologs of human disease genes are replace

SUBMITTER: Katanaev VL 

PROVIDER: S-EPMC10272901 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature