KRAS^G12C mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer.

ABSTRACT: KRAS mutation is the most frequent type of genetic mutation in non-small cell lung cancer (NSCLC), especially in lung adenocarcinoma. However, KRAS mutation can affect many biological processes and the mechanisms underlying KRAS mutation-mediate carcinogenesis in NSCLC have not been fully understood. In this research, we found that KRAS^G12C mutation was associated with the upregulation of T-LAK cell-originated protein kinase (TOPK), which is a well-known serine/threonine MAPK-like protein kinase implicated in tumorigenesis. The overexpression of TOPK significantly promoted the malignant phenotype of A549 cells, and TOPK silencing impaired the malignant phenotype with KRAS^G12C mutation. Moreover, we demonstrated that TOPK level was regulated by MAPK/ERK signalling and

SUBMITTER: Cai C 

PROVIDER: S-EPMC10273069 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature