Customized Scaffolds for Direct Assembly of Functionalized DNA Origami.

ABSTRACT: Functional DNA origami nanoparticles (DNA-NPs) are used as nanocarriers in a variety of biomedical applications including targeted drug delivery and vaccine development. DNA-NPs can be designed into a broad range of nanoarchitectures in one, two, and three dimensions with high structural fidelity. Moreover, the addressability of the DNA-NPs enables the precise organization of functional moieties, which improves targeting, actuation, and stability. DNA-NPs are usually functionalized via chemically modified staple strands, which can be further conjugated with additional polymers and proteins for the intended application. Although this method of functionalization is extremely efficient to control the stoichiometry and organization of functional moieties, fewer than half of the permissible sit

SUBMITTER: Oktay E 

PROVIDER: S-EPMC10273176 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature