Brain alterations associated with overweight evaluated by body mass index or body fat index in an elderly population: the PROOF study.

ABSTRACT:

Background/objectives

Obesity is a complex health issue in which the brain plays a role yet to be determined, especially in the elderly. Indeed, in the ageing population, the balance between fat and lean mass is different; thus, the co-influence between the brain and obesity may differ between the elderly and younger subjects. Our main goal is thus to explore the relationship between the brain and obesity using two different approaches to measure obesity: body mass index (BMI) and an index centred on fat mass, the body fat index (BFI).

Subjects/methods

Among the 1,011 subjects of the PROOF population, 273 subjects aged 75 years underwent 3D magnetic resonance imaging as well as dual-energy X-ray absorptiometry to assess fat mass. Voxel-based morphometry was used to explore t

SUBMITTER: Kassir R 

PROVIDER: S-EPMC10273264 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature