Obesity is associated with impaired postprandial pancreatic polypeptide secretion.

ABSTRACT:

Objective

This study aims to compare the levels of serum pancreatic polypeptide (PP), insulin (INS), C-peptide (C-P), and glucagon (GCG) before and after glucose stimulation in type 2 diabetes mellitus (T2DM) patients with different body mass indexes (BMI), analyze the relevant factors associated with PP secretion, and further investigate the role of PP in the development of obesity and diabetes.

Methods

Data were collected from 83 patients from the hospital. The subjects were divided into normal-weight group, overweight group, and obese group according to their BMI. All subjects were tested with the standard bread meal test (SBMT). PP and relevant parameters were measured, and the area under the curve (AUC) was calculated after 120 min of SBMT. AUC_pp (AUC of PP)

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC10273268 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature