Ontology highlight
ABSTRACT:
SUBMITTER: Sciandrone B
PROVIDER: S-EPMC10273338 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Sciandrone Barbara B Ami Diletta D D'Urzo Annalisa A Angeli Elena E Relini Annalisa A Vanoni Marco M Natalello Antonino A Regonesi Maria Elena ME
Protein science : a publication of the Protein Society 20230701 7
The HspB8-BAG3 complex plays an important role in the protein quality control acting alone or within multi-components complexes. To clarify the mechanism underlying its activity, in this work we used biochemical and biophysical approaches to study the tendency of both proteins to auto-assemble and to form the complex. Solubility and Thioflavin T assays, Fourier transform infrared spectroscopy and atomic force microscopy analyses clearly showed the tendency of HspB8 to self-assemble at high conce ...[more]