Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against H₂O₂-induced oxidative stress via modulation of MAPK and Nrf2/ARE pathways.

ABSTRACT:

Background

Deinococcus radiodurans is a robust bacterium that can withstand harsh environments that cause oxidative stress to macromolecules due to its cellular structure and physiological functions. Cells release extracellular vesicles for intercellular communication and the transfer of biological information; their payload reflects the status of the source cells. Yet, the biological role and mechanism of Deinococcus radiodurans-derived extracellular vesicles remain unclear.

Aim

This study investigated the protective effects of membrane vesicles derived from D. radiodurans (R1-MVs) against H₂O₂-induced oxidative stress in HaCaT cells.

Results

R1-MVs were identified as 322 nm spherical molecules. Pretreatment with R1-MVs inhibited H₂O<

SUBMITTER: Han JM 

PROVIDER: S-EPMC10273539 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature