Metabolic syndrome and the risk of severe cancer events: a longitudinal study in Japanese workers.

ABSTRACT:

Background

Metabolic syndrome (MetS) is associated with cancer risk; however, little is known regarding its relationship with the risk of cancer-related premature death and long-term sick leave (LTSL), which can lead to a substantial loss in working years. The present study aimed to quantify the all-site and site-specific associations between MetS and the risk of severe cancer events (a composite outcome of LTSL and mortality due to cancer) in a large working population in Japan.

Methods

We recruited 70,875 workers (59,950 men and 10,925 women), aged 20-59 years, who attended health check-ups in 2011 (10 companies) and 2014 (2 companies). All workers underwent follow up for severe cancer events until March 31, 2020. MetS was defined in accordance with the Joint Interim State

SUBMITTER: Van Hoang D 

PROVIDER: S-EPMC10273588 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature