A novel dammarane triterpenoid alleviates atherosclerosis by activating the LXRα pathway.

ABSTRACT:

Background

We have previously demonstrated that ginsenoside compound K can attenuate the formation of atherosclerotic lesions. Therefore, ginsenoside compound K has potential for atherosclerosis therapy. How to improve the druggability and enhance the antiatherosclerotic activity of ginsenoside compound K are the core problems in the prevention and treatment of atherosclerosis. CKN is a ginsenoside compound K derivative that was previously reported to have excellent antiatherosclerotic activity in vitro, and we have applied for international patents for it.

Methods

Male C57BL/6 ApoE^-/- mice were fed a high-fat and high-choline diet to induce atherosclerosis and were subjected to in vivo studies. In vitro, the CCK-8 method was applied to evaluate cytotoxicity in ma

SUBMITTER: Huang Y 

PROVIDER: S-EPMC10273626 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature