Predicting tumor repopulation through the gene panel derived from radiation resistant colorectal cancer cells.

ABSTRACT:

Background

Tumor cells with the capability of radiation resistance can escape the fate of cell death after radiotherapy, serving as the main cause of treatment failure. Repopulation of tumors after radiotherapy is dominated by this group of residual cells, which greatly reduce the sensitivity of recurrent tumors to the therapy, resulting in poor clinical outcomes. Therefore, revealing the mechanism of radiation resistant cells participating in tumor repopulation is of vital importance for cancer patients to obtain a better prognosis.

Methods

Co-expressed genes were searched by using genetic data of radiation resistant cells (from GEO database) and TCGA colorectal cancer. Univariate and multivariate Cox regression analysis were performed to define the most significant co-expr

SUBMITTER: Song Y 

PROVIDER: S-EPMC10273655 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature