Identification of miR-143-3p as a diagnostic biomarker in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is among the most common types of gastrointestinal cancers and has a high incidence and mortality around the world. To suppress the progression of GC, it is essential to develop diagnostic markers. MicroRNAs regulate GC development, but a clearer insight into their role is needed before they can be applied as a molecular markers and targets.

Methods

In this study, we assessed the diagnostic value of differentially expressed microRNAs as potential diagnostic biomarkers for GC using data for 389 tissue samples from the Cancer Genome Atlas (TCGA) and 21 plasma samples from GC patients.

Results

The expression of hsa-miR-143-3p (also known as hsa-miR-143) was significantly downregulated in GC according to the TCGA data and plasma samples. The

SUBMITTER: Ju Y 

PROVIDER: S-EPMC10273760 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature