Genetic determinants of LDL cholesterol and risk of intracerebral haemorrhage.

ABSTRACT:

Purpose of review

The role of lipids in spontaneous, nontraumatic intracerebral haemorrhage (ICH) remains controversial, as some studies suggest that lower levels of total and LDL cholesterol could increase the risk of this disease. Because of their random assortment during meiosis, genetic variants known to associate with lipid levels can be used as instruments to evaluate this relationship from a causal perspective. The purpose of this review is to summarize the existing literature related to genetically determined LDL cholesterol levels and risk of ICH.

Recent findings

A number of studies have demonstrated that lower LDL levels are associated with a higher risk of ICH and a higher burden of neuroimaging markers of cerebral small vessel disease, such as microbleeds and whi

SUBMITTER: Szejko N 

PROVIDER: S-EPMC10273781 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature