The Nasal Innate Immune Proteome After Saline Irrigation: A Pilot Study in Healthy Individuals.

ABSTRACT:

Background

Previous research has shown diminished nasal immune function following nasal saline irrigation (NSI), returning to baseline at 6 hours. The aim of this study was to examine the immune nasal proteome before and after 14 days of nasal irrigation.

Methods

Seventeen healthy volunteers received either isotonic (IsoSal) or low salt (LowNa) NSI. Nasal secretions were collected before and 30 min after NSI at baseline and again after 14 days. Specimens were analyzed using mass spectrometry to detect proteins of relevance to nasal immune function.

Results

One thousand eight hundred and sixty-five proteins were identified with significant changes in 71 proteins, of which 23 were identified as part of the innate immune system. Baseline analysis demonstrated an increase

SUBMITTER: Harcourt-Smith EA 

PROVIDER: S-EPMC10273869 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature