Efficacy of Double Membrane Filtration Immunoadsorption in Severe C1q-Binding Donor-Specific Antibody-Positive Acute Humoral Kidney Allograft Rejection: A Case Series.

ABSTRACT:

Introduction

Acute antibody-mediated rejection (ABMR) is an important threat to renal allograft survival in the early transplant period and the major single cause of graft loss in the first postoperative year. Semi-selective immunoadsorption (IA) remains one of the commonly applied treatments in ABMR, reducing allo-reactive antibody load. Adding double filtration plasmapheresis (DFPP) to IA might enhance therapeutic efficacy by also addressing innate humoral effectors like complement factors.

Methods

Four patients with ABMR were treated with DFPP + IA. Clinical, histological, and immunological data and adverse events were retrospectively collected.

Results

Here we present four high-risk treatment-refractory ABMR cases with C1q-binding donor-specific antibodies and his

SUBMITTER: Russwurm M 

PROVIDER: S-EPMC10273878 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature