Data-Driven Blood Transfusion Thresholds for Severely Injured Patients During Blood Shortages.

ABSTRACT:

Introduction

Crises like the COVID-19 pandemic create blood product shortages. Patients requiring transfusions are placed at risk and institutions may need to judiciously administer blood during massive blood transfusions protocols (MTP). The purpose of this study is to provide data-driven guidance for the modification of MTP when the blood supply is severely limited.

Methods

This is a retrospective cohort study of 47 Level I and II trauma centers (TC) within a single healthcare system whose patients received MTP from 2017 to 2019. All TC used a unifying MTP protocol for balanced blood product transfusions. The primary outcome was mortality as a function of volume of blood transfused and age. Hemoglobin thresholds and measures of futility were also estimated. Risk-adjusted a

SUBMITTER: Ang D 

PROVIDER: S-EPMC10274455 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature