Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation.

ABSTRACT: Parasitic helminths influence the composition of the gut microbiome. However, the microbiomes of individuals living in helminth-endemic regions are understudied. The Orang Asli, an indigenous population in Malaysia with high burdens of the helminth Trichuris trichiura, displayed microbiotas enriched in Clostridiales, an order of spore-forming obligate anaerobes previously shown to have immunogenic properties. We previously isolated novel Clostridiales that were enriched in these individuals and found that a subset promoted the Trichuris life cycle. Here, we further characterized the functional properties of these bacteria. Enzymatic and metabolomic profiling revealed a range of activities associated with metabolism and host response. Consistent with this finding, monocoloniza

SUBMITTER: Sargsian S 

PROVIDER: S-EPMC10274677 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature