Defining Microbial Community Functions in Chronic Human Infection with Metatranscriptomics.

ABSTRACT: Chronic polymicrobial infections (cPMIs) harbor complex bacterial communities with diverse metabolic capacities, leading to competitive and cooperative interactions. Although the microbes present in cPMIs have been established through culture-dependent and-independent methods, the key functions that drive different cPMIs and the metabolic activities of these complex communities remain unknown. To address this knowledge gap, we analyzed 102 published metatranscriptomes collected from cystic fibrosis sputum (CF) and chronic wound infections (CW) to identify key bacterial members and functions in cPMIs. Community composition analysis identified a high prevalence of pathogens, particularly Staphylococcus and Pseudomonas, and anaerobic members of the microbiota, including Porph

SUBMITTER: Adekoya AE 

PROVIDER: S-EPMC10274682 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature