Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer.

ABSTRACT: Neuronal and behavioral adaptations to novel stimuli are regulated by temporally dynamic waves of transcriptional activity, which shape neuronal function and guide enduring plasticity. Neuronal activation promotes expression of an immediate early gene (IEG) program comprised primarily of activity-dependent transcription factors, which are thought to regulate a second set of late response genes (LRGs). However, while the mechanisms governing IEG activation have been well studied, the molecular interplay between IEGs and LRGs remain poorly characterized. Here, we used transcriptomic and chromatin accessibility profiling to define activity-driven responses in rat striatal neurons. As expected, neuronal depolarization generated robust changes in gene expression, with early changes (1 h) enrich

SUBMITTER: Phillips RA 

PROVIDER: S-EPMC10274686 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature