Necessary Role of Acute Ceramide Formation in The Human Microvascular Endothelium During Health and Disease.

ABSTRACT:

Background

Elevated plasma ceramides independently predict adverse cardiac events and we have previously shown that exposure to exogenous ceramide induces microvascular endothelial dysfunction in arterioles from otherwise healthy adults (0-1 risk factors for heart disease). However, evidence also suggests that activation of the shear-sensitive, ceramide forming enzyme neutral sphingomyelinase (NSmase) enhances vasoprotective nitric oxide (NO) production. Here we explore a novel hypothesis that acute ceramide formation through NSmase is necessary for maintaining NO signaling within the human microvascular endothelium. We further define the mechanism through which ceramide exerts beneficial effects and discern key mechanistic differences between arterioles from otherwise healthy adul

SUBMITTER: SenthilKumar G 

PROVIDER: S-EPMC10274701 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature