The consequences of tetraploidy on Caenorhabditis elegans physiology and sensitivity to chemotherapeutics.

ABSTRACT: Polyploid cells contain more than two copies of each chromosome. Polyploidy has important roles in development, evolution, and tissue regeneration/repair, and can arise as a programmed polyploidization event or be triggered by stress. Cancer cells are often polyploid. C. elegans nematodes are typically diploid, but stressors such as heat shock and starvation can trigger the production of tetraploid offspring. In this study, we utilized a recently published protocol to generate stable tetraploid strains of C. elegans and compared their physiological traits and sensitivity to two DNA-damaging chemotherapeutic drugs, cisplatin and doxorubicin. As prior studies have shown, tetraploid worms are approximately 30% longer, shorter-lived, and have a smaller brood size than diploids. W

SUBMITTER: Misare KR 

PROVIDER: S-EPMC10274754 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature