Heritable epigenetic changes are constrained by the dynamics of regulatory architectures.

ABSTRACT: Interacting molecules create regulatory architectures that can persist despite turnover of molecules. Although epigenetic changes occur within the context of such architectures, there is limited understanding of how they can influence the heritability of changes. Here I develop criteria for the heritability of regulatory architectures and use quantitative simulations of interacting regulators parsed as entities, their sensors and the sensed properties to analyze how architectures influence heritable epigenetic changes. Information contained in regulatory architectures grows rapidly with the number of interacting molecules and its transmission requires positive feedback loops. While these architectures can recover after many epigenetic perturbations, some resulting changes can become perman

SUBMITTER: Jose AM 

PROVIDER: S-EPMC10274868 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature