A non-oscillatory, millisecond-scale embedding of brain state provides insight into behavior.

ABSTRACT: Sleep and wake are understood to be slow, long-lasting processes that span the entire brain. Brain states correlate with many neurophysiological changes, yet the most robust and reliable signature of state is enriched in rhythms between 0.1 and 20 Hz. The possibility that the fundamental unit of brain state could be a reliable structure at the scale of milliseconds and microns has not been addressed due to the physical limits associated with oscillation-based definitions. Here, by analyzing high resolution neural activity recorded in 10 anatomically and functionally diverse regions of the murine brain over 24 h, we reveal a mechanistically distinct embedding of state in the brain. Sleep and wake states can be accurately classified from on the order of 10 ⁰ to 10 ¹ ms

SUBMITTER: Parks DF 

PROVIDER: S-EPMC10274881 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature