Exercise-primed extracellular vesicles improve cell-matrix adhesion and chondrocyte health.

ABSTRACT: Extracellular vesicles (EVs) have been suggested to transmit the health-promoting effects of exercise throughout the body. Yet, the mechanisms by which beneficial information is transmitted from extracellular vesicles to recipient cells are poorly understood, precluding a holistic understanding of how exercise promotes cellular and tissue health. In this study, using articular cartilage as a model, we introduced a network medicine paradigm to simulate how exercise facilitates communication between circulating EVs and chondrocytes, the cells resident in articular cartilage. Using the archived small RNA-seq data of EV before and after aerobic exercise, microRNA regulatory network analysis based on network propagation inferred that circulating EVs activated by aerobic exercise perturb chondro

SUBMITTER: Iijima H 

PROVIDER: S-EPMC10274961 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature