Combined GWAS and single cell transcriptomics uncover the underlying genes and cell types in disorders of gut-brain interaction.

ABSTRACT: Disorders of gut-brain interaction (DGBIs), formerly known as functional gastrointestinal disorders, are extremely common and historically difficult to manage. This is largely because their cellular and molecular mechanisms have remained poorly understood and understudied. One approach to unravel the molecular underpinnings of complex disorders such as DGBIs is performing genome wide association studies (GWASs). However, due to the heterogenous and non-specific nature of GI symptoms, it has been difficult to accurately classify cases and controls. Thus, to perform reliable studies, we need to access large patient populations which has been difficult to date. Here, we leveraged the UK Biobank (UKBB) database, containing genetic and medical record data of over half a million individuals, to

SUBMITTER: Majd A 

PROVIDER: S-EPMC10275016 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature