Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability.

ABSTRACT:

Background

Mycobacterium tuberculosis (M.tb), the causative bacterium of tuberculosis (TB), establishes residence and grows in human alveolar macrophages (AMs). Inter-individual variation in M.tb-human AM interactions can indicate TB risk and the efficacy of therapies and vaccines; however, we currently lack an understanding of the gene and protein expression programs that dictate this variation in the lungs.

Results

Herein, we systematically analyze interactions of a virulent M.tb strain H₃₇R_v with freshly isolated human AMs from 28 healthy adult donors, measuring host RNA expression and secreted candidate proteins associated with TB pathogenesis over 72h. A large set of genes possessing highly variable inter-individual expr

SUBMITTER: Sadee W 

PROVIDER: S-EPMC10275041 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature