Factors improving overall survival in breast cancer patients with leptomeningeal disease (LMD): A single institutional retrospective review.

ABSTRACT:

Background

Breast cancer-related leptomeningeal disease (BC-LMD) is a dire diagnosis for 5-8% of patients with breast cancer (BC). We conducted a retrospective review of BC-LMD patients diagnosed at Moffitt Cancer Center (MCC) from 2011-2020, to determine the changing incidence of BC-LMD, which factors impact progression of BC CNS metastasis to BC-LMD, and which factors affect OS for patients with BC-LMD.

Methods

Patients with BC and brain/spinal metastatic disease were identified. For those who eventually developed BC-LMD, we used Kaplan-Meier survival curve, log-rank test, univariable, and multivariate Cox proportional hazards regression model to identify factors affecting time from CNS metastasis to BC-LMD and OS.

Results

128 cases of BC-LMD were identified. The pr

SUBMITTER: Wallace G 

PROVIDER: S-EPMC10275046 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature