Sex differences in multilayer functional network topology over the course of aging in 37543 UK Biobank participants.

ABSTRACT: Aging is a major risk factor for cardiovascular and neurodegenerative disorders, with considerable societal and economic implications. Healthy aging is accompanied by changes in functional connectivity between and within resting-state functional networks, which have been associated with cognitive decline. However, there is no consensus on the impact of sex on these age-related functional trajectories. Here, we show that multilayer measures provide crucial information on the interaction between sex and age on network topology, allowing for better assessment of cognitive, structural, and cardiovascular risk factors that have been shown to differ between men and women, as well as providing additional insights into the genetic influences on changes in functional connectivity that occur during

SUBMITTER: Mijalkov M 

PROVIDER: S-EPMC10275214 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature