COR388 (atuzaginstat): an investigational gingipain inhibitor for the treatment of Alzheimer disease.

ABSTRACT:

Introduction

Evidence from in vitro and in vivo studies demonstrates that amyloid beta (Aβ) oligomers have potent, broad-spectrum antimicrobial properties created by fibrils that entrap pathogens and disrupt their membranes. Data suggest that Aβ may play a protective role in the innate immune response to microbial infections and that Aβ in the brain plays a damaging role when the inflammatory response is not well controlled.

Areas covered

This paper describes the relationship between periodontal disease and Alzheimer disease (AD), the role of Porphyromonas gingivalis and its secreted gingipains in AD, and the potential of the gingipain inhibitor atuzaginstat (COR388) to modulate AD neuropathologies.

Expert opinion

P. gingivalis is opsonized by Aβ42, is c

SUBMITTER: Sabbagh MN 

PROVIDER: S-EPMC10275298 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature